Maprouneacin, a new daphnane diterpenoid with potent antihyperglycemic activity from Maprounea africana

被引：36

作者：

Carney, JR ^{[1
]}

Krenisky, JM

Williamson, RT

Luo, J

Carlson, TJ

Hsu, VL

Moswa, JL

机构：

[1] Shaman Pharmaceut Inc, 213 E Grand Ave, San Francisco, CA 94080 USA

[2] Oregon State Univ, Dept Biochem & Chem, Corvallis, OR 97331 USA

[3] Oregon State Univ, Dept Biophys, Corvallis, OR 97331 USA

[4] Univ Kinshasa, Fac Pharm, Kinshasa, DEM REP CONGO

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 02期

关键词：

D O I：

10.1021/np980356c

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of the EtOH extract of M. africana, using the in vivo noninsulin-dependent diabetes mellitus db/db mouse model, resulted in the isolation of the new daphnane-type diterpenoid maprouneacin (2). Compound 2 showed potent glucose-lowering properties when given by the oral route.

引用

页码：345 / 347

页数：3

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