General Anesthetic Actions on GABAA Receptors

被引：194

作者：

Garcia, Paul S.

Kolesky, Scott E.

Jenkins, Andrew ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Rollins Res Ctr, Dept Anesthesiol, Atlanta, GA 30322 USA

来源：

CURRENT NEUROPHARMACOLOGY | 2010年 / 8卷 / 01期

关键词：

GABA(A) Receptor; General Anesthetic; Isoflurane; Desflurane; Sevoflurane; Propofol; Etomidate; Barbiturates; ACID TYPE-A; INHIBITORY POSTSYNAPTIC CURRENTS; SUBUNIT MESSENGER-RNAS; GATED ION CHANNELS; VOLATILE ANESTHETICS; HIPPOCAMPAL-NEURONS; INHALED ANESTHETICS; GLYCINE RECEPTORS; OPTICAL ISOMERS; ALPHA-1; SUBUNIT;

D O I：

10.2174/157015910790909502

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

General anesthetic drugs interact with many receptors in the nervous system, but only a handful of these interactions are critical for producing anesthesia. Over the last 20 years, neuropharmacologists have revealed that one of the most important target sites for general anesthetics is the GABA(A) receptor. In this review we will discuss what is known about anesthetic - GABA(A) receptor interactions.

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页码：2 / 9

页数：8

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