Cutaneous melanoma

被引:493
作者
Thompson, JF
Scolyer, RA
Kefford, RF
机构
[1] Univ Sydney, Royal Prince Alfred Hosp, Sydney Melanoma Unit, Camperdown, NSW 2050, Australia
[2] Westmead Hosp, Sydney, NSW, Australia
关键词
D O I
10.1016/S0140-6736(05)17951-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Episodic exposure of fair-skinned individuals to intense sunlight is thought to be responsible for the steadily increasing melanoma incidence worldwide over recent decades. Rarely, melanoma susceptibility is increased more than tenfold by heritable mutations in the cell cycle regulatory genes CDKN2A and CDK4. Effective treatment requires early diagnosis followed by surgical excision with adequately wide margins. Sentinel lymph node biopsy provides accurate staging, but no published results are yet available from clinical trials designed to assess the therapeutic efficacy of early complete regional node dissection in those with metastatic disease in a sentinel node. Magnetic resonance spectroscopy is one technique under investigation for non-invasive, in-situ assessment of sentinel nodes. localised metastatic disease is best treated surgically. No postoperative adjuvant therapy is of proven value for improving overall survival, although numerous clinical trials of vaccines and cytokines are in progress. Medical therapies have contributed little to the control of established metastatic disease, but molecular pathways recently identified as being central to melanoma growth and apoptosis are under intense investigation for their potential as therapeutic targets.
引用
收藏
页码:687 / 701
页数:15
相关论文
共 196 条
[91]  
HERSEY P, 2004, TXB MELANOMA, P559
[92]   Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients [J].
Hodi, FS ;
Mihm, MC ;
Soiffer, RJ ;
Haluska, FG ;
Butler, M ;
Seiden, MV ;
Davis, T ;
Henry-Spires, R ;
MacRae, S ;
Willman, A ;
Padera, R ;
Jaklitsch, MT ;
Shankar, S ;
Chen, TC ;
Korman, A ;
Allison, JP ;
Dranoff, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (08) :4712-4717
[93]   bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice [J].
Jansen, B ;
Schlagbauer-Wadl, H ;
Brown, BD ;
Bryan, RN ;
van Elsas, A ;
Müller, M ;
Wolff, K ;
Eichler, HG ;
Pehamberger, H .
NATURE MEDICINE, 1998, 4 (02) :232-234
[94]   Reliability of sentinel lymph node biopsy for staging melanoma [J].
Jansen, L ;
Nieweg, OE ;
Peterse, JL ;
Hoefnagel, CA ;
Olmos, RAV ;
Kroon, BBR .
BRITISH JOURNAL OF SURGERY, 2000, 87 (04) :484-489
[95]   Cancer statistics, 2004 [J].
Jemal, A ;
Tiwari, RC ;
Murray, T ;
Ghafoor, A ;
Samuels, A ;
Ward, E ;
Feuer, EJ ;
Thun, MJ .
CA-A CANCER JOURNAL FOR CLINICIANS, 2004, 54 (01) :8-29
[96]   Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens [J].
Jensen, P ;
Hansen, S ;
Moller, B ;
Leivestad, T ;
Pfeffer, P ;
Geiran, O ;
Fauchald, P ;
Simonsen, S .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 40 (02) :177-186
[97]   Outcome in 846 cutaneous melanoma patients from a single center after negative sentinel node biopsy [J].
Ka, VS ;
Thompson, JF ;
McKinnon, JG ;
Scolyer, RA ;
Li, LX ;
Uren, R .
ANNALS OF SURGICAL ONCOLOGY, 2004, 11 (02) :S60-S60
[98]   Genetic testing for melanoma [J].
Kefford, R ;
Bishop, JN ;
Tucker, M ;
Bressac-de-Paillerets, B ;
Bianchi-Scarrá, G ;
Bergman, W ;
Goldstein, A ;
Puig, S ;
Mackie, R ;
Elder, D ;
Hansson, J ;
Hayward, N ;
Hogg, D ;
Olsson, H .
LANCET ONCOLOGY, 2002, 3 (11) :653-654
[99]   Adjuvant therapy of cutaneous melanoma: the interferon debate [J].
Kefford, RE .
ANNALS OF ONCOLOGY, 2003, 14 (03) :358-365
[100]   Is there a role for genetic testing in patients with melanoma? [J].
Kefford, RF ;
Mann, GJ .
CURRENT OPINION IN ONCOLOGY, 2003, 15 (02) :157-161