On the preparative use of recombinant β(1-3)galactosyl-transferase

被引：18

作者：

Baisch, G ^{[1
]}

Öhrlein, R ^{[1
]}

Streiff, M ^{[1
]}

Kolbinger, F ^{[1
]}

机构：

[1] Novartis Pharma AG, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(98)00093-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of non-natural N-acyl derivatives of glucosamine is incubated with a recombinant beta(1-3)galactosyl-transferase and UDP-galactose. Surprisingly, the enzyme recognizes the non-natural accepters as substrates and transfers galactose onto the 3-OH group in a beta-mode to give a series of Lewis(c)-(type 1) disaccharides. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：751 / 754

页数：4

共 18 条

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