Suggested improved method for the Ing-Manske and related reactions for the second step of Gabriel synthesis of primary amines

被引：13

作者：

Ariffin, A ^{[1
]}

Khan, MN ^{[1
]}

Lan, LC ^{[1
]}

May, FY ^{[1
]}

Yun, CS ^{[1
]}

机构：

[1] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 24期

关键词：

Gabriel synthesis; Ing-Manske procedure; N-substituted phthalimides; aminolysis;

D O I：

10.1081/SCC-200043164

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work demonstrates an improvement in the Ing-Manske and related procedures by the increase of pH of the reaction mixture after the complete disappearance of N-substituted phthalimide. Hydrazinolysis of N-phenylphthalimide (1a) gave 80% of the desired primary amines after 5.3 h in the absence of added NaOH. The reaction time was reduced to 1.6 h and 1.2 h when 1 eq. and 5 eq. of NaOH were added to the reaction mixture after the complete disappearance of 1a. Hydroxyaminolysis of N-(4-ethylphenyl)phthalimide (1b) gave 80% of the desired primary amines after 7.5 h of reaction time (at added [NaOH] = 0). When 10 eq. and 20 eq. of NaOH were added to the reaction mixture after the disappearance of 1b, the reaction time was reduced to 4 h and 2 h, respectively. Methylaminolysis of N-(2-ethylphenyl)phthalimide (1c) gave 80% of the desired primary amines after 1.7 h (at added [NaOH] = 0). The reaction time was reduced to 1 h and 0.7 h when 1 eq. and 25 eq. of NaOH were added to the reaction mixture after the complete disappearance of 1c.

引用

页码：4439 / 4445

页数：7