Inflammasomes: too big to miss

被引：265

作者：

Stutz, Andrea ^{[1
]}

Golenbock, Douglas T. ^{[1
]}

Latz, Eicke ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Immunol & Infect Dis, Worcester, MA 01605 USA

[2] Univ Bonn, Inst Innate Immun, D-5300 Bonn, Germany

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 12期

关键词：

NF-KAPPA-B; ANTHRAX LETHAL TOXIN; INNATE IMMUNE-RESPONSE; INTERLEUKIN-1-BETA CONVERTING-ENZYME; CONTAINING APAF1-LIKE PROTEIN; MEDIATED IL-1-BETA SECRETION; FAMILIAL MEDITERRANEAN FEVER; PATHOGEN CANDIDA-ALBICANS; CASPASE-1; ACTIVATION; NALP3; INFLAMMASOME;

D O I：

10.1172/JCI40599

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inflammation is the coordinated immune response to,harmful stimuli that appear during infections or after tissue damage. Cells of the innate immune system are the central players in mediating inflammatory tissue responses. These cells are equipped with an array of signaling receptors that detect foreign molecular substances or altered endogenous molecules that appear under situations of stress. This review provides an overview of recent progress in elucidating the molecular mechanisms that lead to inflammatory reactions. We discuss the current knowledge of the mechanisms leading to the activation of cytoplasmic, multimolecular protein complexes, termed "inflammasomes," which regulate the activity of caspase-1 and the maturation and release of IL-1 beta.

引用

页码：3502 / 3511

页数：10

共 136 条

[121] The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1 [J].

Thomas, Paul G. ;

Dash, Pradyot ;

Aldridge, Jerry R., Jr. ;

Ellebedy, Ali H. ;

Reynolds, Cory ;

Funk, Amy J. ;

Martin, William J. ;

Lamkanfi, Mohamed ;

Webby, Richard J. ;

Boyd, Kelli L. ;

Doherty, Peter C. ;

Kanneganti, Thirumala-Devi .

IMMUNITY, 2009, 30 (04) :566-575

[122] A NOVEL HETERODIMERIC CYSTEINE PROTEASE IS REQUIRED FOR INTERLEUKIN-1-BETA PROCESSING IN MONOCYTES [J].

THORNBERRY, NA ;

BULL, HG ;

CALAYCAY, JR ;

CHAPMAN, KT ;

HOWARD, AD ;

KOSTURA, MJ ;

MILLER, DK ;

MOLINEAUX, SM ;

WEIDNER, JR ;

AUNINS, J ;

ELLISTON, KO ;

AYALA, JM ;

CASANO, FJ ;

CHIN, J ;

DING, GJF ;

EGGER, LA ;

GAFFNEY, EP ;

LIMJUCO, G ;

PALYHA, OC ;

RAJU, SM ;

ROLANDO, AM ;

SALLEY, JP ;

YAMIN, TT ;

LEE, TD ;

SHIVELY, JE ;

MACCROSS, M ;

MUMFORD, RA ;

SCHMIDT, JA ;

TOCCI, MJ .

NATURE, 1992, 356 (6372) :768-774

[123] The NLR gene family: A standard nomenclature [J].

Ting, Jenny P. -Y. ;

Lovering, Ruth C. ;

Alnemri, Emad S. ;

Bertin, John ;

Boss, Jeremy M. ;

Davis, Beckley K. ;

Flavell, Richard A. ;

Girardin, Stephen E. ;

Godzik, Adam ;

Harton, Jonathan A. ;

Hoffman, Hal M. ;

Hugot, Jean-Pierre ;

Inohara, Naohiro ;

MacKenzie, Alex ;

Maltais, Lois J. ;

Nunez, Gabriel ;

Ogura, Yasunori ;

Otten, Luc A. ;

Philpott, Dana ;

Reed, John C. ;

Reith, Walter ;

Schreiber, Stefan ;

Steimle, Viktor ;

Ward, Peter A. .

IMMUNITY, 2008, 28 (03) :285-287

[124] NLRs at the intersection of cell death and immunity [J].

Ting, Jenny P. -Y. ;

Willingham, Stephen B. ;

Bergstralh, Daniel T. .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (05) :372-379

[125] Bypassing Pathogen-Induced Inflammasome Activation for the Regulation of Interleukin-1β Production by the Fungal Pathogen Candida albicans [J].

van de Veerdonk, Frank L. ;

Joosten, Leo A. B. ;

Devesa, Isabel ;

Mora-Montes, Hector M. ;

Kanneganti, Thirumala-Devi ;

Dinarello, Charles A. ;

van der Meer, Jos W. M. ;

Gow, Neil A. R. ;

Kullberg, Bart Jan ;

Netea, Mihai G. .

JOURNAL OF INFECTIOUS DISEASES, 2009, 199 (07) :1087-1096

[126] POTASSIUM-INHIBITED PROCESSING OF IL-1-BETA IN HUMAN MONOCYTES [J].

WALEV, I ;

RESKE, K ;

PALMER, M ;

VALEVA, A ;

BHAKDI, S .

EMBO JOURNAL, 1995, 14 (08) :1607-1614

[127] PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-κB and caspase-1-dependent cytokine processing [J].

Wang, L ;

Manji, GA ;

Grenier, JM ;

Al-Garawi, A ;

Merriam, S ;

Lora, JM ;

Geddes, BJ ;

Briskin, M ;

DiStefano, PS ;

Bertin, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (33) :29874-29880

[128] Activation of the IL-1β-Processing inflammasome is involved in contact hypersensitivity [J].

Watanabe, Hideki ;

Gaide, Olivier ;

Petrilli, Virginie ;

Martinon, Fabio ;

Contassot, Emmanuel ;

Roques, Stéphanie ;

Kummer, Jean A. ;

Tschopp, Juerg ;

French, Lars E. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2007, 127 (08) :1956-1963

[129] Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasome [J].

Wickliffe, Katherine E. ;

Leppla, Stephen H. ;

Moayeri, Mahtab .

CELLULAR MICROBIOLOGY, 2008, 10 (02) :332-343

[130] STRUCTURE AND MECHANISM OF INTERLEUKIN-1-BETA CONVERTING-ENZYME [J].

WILSON, KP ;

BLACK, JAF ;

THOMSON, JA ;

KIM, EE ;

GRIFFITH, JP ;

NAVIA, MA ;

MURCKO, MA ;

CHAMBERS, SP ;

ALDAPE, RA ;

RAYBUCK, SA ;

LIVINGSTON, DJ .

NATURE, 1994, 370 (6487) :270-275

← 5 6 7 8 9 10 11 12 13 14 →