Synthesis and conformation of 3'-O,4'-C-methyleneribonucleosides, novel bicyclic nucleoside analogues for 2',5'-linked oligonucleotide modification

被引：63

作者：

Obika, S ^{[1
]}

Morio, K ^{[1
]}

Nanbu, D ^{[1
]}

Imanishi, T ^{[1
]}

机构：

[1] OSAKA UNIV,FAC PHARMACEUT SCI,SUITA,OSAKA 565,JAPAN

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 17期

关键词：

D O I：

10.1039/a704376g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel bicyclic nucleoside analogues 3'-O,4'-C-methylene-ribonucleosides 1 are conveniently prepared starting from uridine; the sugar puckering of 1 is found to be nearly in the S-conformation by means of PM3 calculations and H-1 NMR studies.

引用

页码：1643 / 1644

页数：2

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