Role of c-Myc in Apc mutant intestinal phenotype:: Case closed or time for a new beginning?

被引：10

作者：

Bommer, Guido T.

Fearon, Eric R. ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Human Genet, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

CANCER CELL | 2007年 / 11卷 / 05期

关键词：

D O I：

10.1016/j.ccr.2007.04.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene occurs in most colorectal cancers. The proto-oncogene c-MYC was one of the first genes linked to APC inactivation, but the in vivo significance of c-MYC's enhanced expression in intestinal cells with APC defects has been uncertain. Sansom et al. recently reported that targeted inactivation of c-Myc in murine intestinal epithelium potently inhibited phenotypical and transcriptional changes seen in Apc-deficient intestinal epithelium. While these findings are very interesting, some questions remain about the assignment of c-Myc as the pre-eminent beta-catenin-regulated gene in intestinal epithelium.

引用

页码：391 / 394

页数：4

共 10 条

[1] β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB [J].

Batlle, E ;

Henderson, JT ;

Beghtel, H ;

van den Born, MMW ;

Sancho, E ;

Huls, G ;

Meeldijk, J ;

Robertson, J ;

van de Wetering, M ;

Pawson, T ;

Clevers, H .

CELL, 2002, 111 (02) :251-263

[2] The c-Myc target gene network [J].

Dang, Chi V. ;

O'Donnell, Kathryn A. ;

Zeller, Karen I. ;

Nguyen, Tam ;

Osthus, Rebecca C. ;

Li, Feng .

SEMINARS IN CANCER BIOLOGY, 2006, 16 (04) :253-264

[3] Identification of c-MYC as a target of the APC pathway [J].

He, TC ;

Sparks, AB ;

Rago, C ;

Hermeking, H ;

Zawel, L ;

da Costa, LT ;

Morin, PJ ;

Vogelstein, B ;

Kinzler, KW .

SCIENCE, 1998, 281 (5382) :1509-1512

[4] Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract:: Effect of loss of β-catenin [J].

Ireland, H ;

Kemp, R ;

Houghton, C ;

Howard, L ;

Clarke, AR ;

Sansom, OJ ;

Winton, DJ .

GASTROENTEROLOGY, 2004, 126 (05) :1236-1246

[5] Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 [J].

Korinek, V ;

Barker, N ;

Moerer, P ;

van Donselaar, E ;

Huls, G ;

Peters, PJ ;

Clevers, H .

NATURE GENETICS, 1998, 19 (04) :379-383

[6] The intestinal epithelial stem cell [J].

Marshman, E ;

Booth, C ;

Potten, CS .

BIOESSAYS, 2002, 24 (01) :91-98

[7] Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc [J].

Muncan, Vanesa ;

Sansom, Owen J. ;

Tertoolen, Leon ;

Phesse, Toby J. ;

Begthel, Harry ;

Sancho, Elena ;

Cole, Alicia M. ;

Gregorieff, Alex ;

de Alboran, Ignacio Moreno ;

Clevers, Hans ;

Clarke, Alan R. .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (22) :8418-8426

[8] Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration [J].

Sansom, OJ ;

Reed, KR ;

Hayes, AJ ;

Ireland, H ;

Brinkmann, H ;

Newton, IP ;

Batlle, E ;

Simon-Assmann, P ;

Clevers, H ;

Nathke, IS ;

Clarke, AR ;

Winton, DJ .

GENES & DEVELOPMENT, 2004, 18 (12) :1385-1390

[9] Myc deletion rescues Apc deficiency in the small intestine [J].

Sansom, Owen J. ;

Meniel, Valerie S. ;

Muncan, Vanesa ;

Phesse, Toby J. ;

Wilkins, Julie A. ;

Reed, Karen R. ;

Vass, J. Keith ;

Athineos, Dimitris ;

Clevers, Hans ;

Clarke, Alan R. .

NATURE, 2007, 446 (7136) :676-679

[10] The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells [J].

van de Wetering, M ;

Sancho, E ;

Verweij, C ;

de Lau, W ;

Oving, I ;

Hurlstone, A ;

van der Horn, K ;

Batlle, E ;

Coudreuse, D ;

Haramis, AP ;

Tion-Pon-Fong, M ;

Moerer, P ;

van den Born, M ;

Soete, G ;

Pals, S ;

Eilers, M ;

Medema, R ;

Clevers, H .

CELL, 2002, 111 (02) :241-250

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