"O-acyl isopeptide method" for peptide synthesis:: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH

被引：43

作者：

Yoshiya, Taku

Taniguchi, Atsuhiko

Sohma, Youhei

Fukao, Fukue

Nakamura, Setsuko

Abe, Naoko

Ito, Nui

Skwarczynski, Mariusz

Kimura, Tooru

Hayashi, Yoshio

Kiso, Yoshiaki ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, 21st Century COE Program, Ctr Frontier Res Med Sci, Dept Med Chem,Yamashina Ku, Kyoto 6078412, Japan

[2] Kyoto Pharmaceut Univ, 21st Century COE Program, Dept Chem Phys, Kyoto 6078412, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 11期

关键词：

SEQUENCE-CONTAINING PEPTIDES; BIOLOGY-ORIENTED SYNTHESIS; VIRUS MATRIX PROTEIN; EFFICIENT SYNTHESIS; MIGRATION REACTION; PROTECTING GROUPS; SWITCH-PEPTIDES; CLICK PEPTIDE; RAPID REMOVAL; AMINO-ACIDS;

D O I：

10.1039/b702284k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The O-acyl isopeptide method has recently received attention as an efficient synthetic method for peptides. Herein, forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH (1-40) were effectively synthesized in two-steps without epimerization. The O-acyl isodipeptide units are important building blocks to enable the routine use of the O-acyl isopeptide method.

引用

页码：1720 / 1730

页数：11

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