Glycogen synthase kinase 3: A key regulator of cellular fate

被引：328

作者：

Forde, J. E. ^{[1
]}

Dale, T. C. ^{[1
]}

机构：

[1] Cardiff Sch Biosci, Cardiff CF10 3US, Wales

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2007年 / 64卷 / 15期

基金：

英国生物技术与生命科学研究理事会;

关键词：

glycogen synthase kinase-3 (GSK-3); mechanism of action; inhibitors; signalling; disease; kinase; regulation;

D O I：

10.1007/s00018-007-7045-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified as a key regulator of insulin-dependent glycogen synthesis. GSK-3 was subsequently shown to function in a wide range of cellular processes including differentiation, growth, motility and apoptosis. Aberrant regulation of GSK-3 has been implicated in a range of human pathologies including Alzheimer's disease, non-insulin dependent diabetes mellitus ( NIDDM) and cancer. As a consequence, the regulation of GSK-3 and the therapeutic potential of GSK-3 inhibitors have become key areas of investigation. This review will focus on the mechanisms of GSK-3 regulation, with emphasis on modulation by upstream signals, control of substrate specificity and GSK-3 localisation. The details of these mechanisms will be discussed in the context of specific signalling pathways.

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页码：1930 / 1944

页数：15

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