Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model

被引：93

作者：

Warawa, J ^{[1
]}

Woods, DE ^{[1
]}

机构：

[1] Univ Calgary, Hlth Sci Ctr, Dept Microbiol & Infect Dis, Calgary, AB T2N 4N1, Canada

来源：

FEMS MICROBIOLOGY LETTERS | 2005年 / 242卷 / 01期

基金：

加拿大健康研究院;

关键词：

melioidosis; Blurkholderia pseudomallei; type III secretion; animal studies; attenuation;

D O I：

10.1016/j.femsle.2004.10.045

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Burkholderia pseudoinallei, the etiological agent of melioidosis, is an animal pathogen capable of inducing a highly fatal septicemia. R pseudomallei possesses three type III secretion system (TTSS) clusters, two of which (TTSS I and TTSS2) are homologous to the TTSS of the plant pathogen Ralstonia solanacearum, and one (TTSS3) is homologous to the Salmonella SPI-I mammalian pathogenicity island. We have demonstrated that TTSS3 is required for the full virulence of B. pseudomallei in a hamster model of infection. We have also examined the virulence of R pseudomallei mutants deficient in several putative TTSS3 effector molecules, and found no significant attenuation of B. pseudomallei virulence in the hamster model. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：101 / 108

页数：8

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