A physical model of the human systemic arterial tree

被引:15
作者
Ferrari, G
Nicoletti, A
De Lazzari, C
Clemente, F
Tosti, G
Guaragno, M
Mimmo, R
Ambrosi, D
Górczynska, K
机构
[1] CNR, Ist Tecnol Biomed, Reparto Ingn Cardiovasc, I-00161 Rome, Italy
[2] Polish Acad Sci, Inst Biocybernet & Biomed Engn, Warsaw, Poland
关键词
heart assist device; cardiovascular models; in vitro; ventricular elastance; arterial elastance;
D O I
10.1177/039139880002300909
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A physical model of the human arterial tree has been developed to be used in a computer controlled mock circulatory system (MCS). Its aim is to represent systemic arterial tree properties and extend the capacity of the MCS to intraortic balloon pump (IABP) testing. The main problem was to model the aorta simply and to accurately reproduce aortic impedance and related flow and pressure waveforms at different sections. The model is composed of eight segments; lumped parameter models are used for its peripheral loads. After the numerical simulation, the physical model was reproduced as a silicon rubber tapered tube. This rubber was chosen for its stability over time and the acceptable behaviour of its Young's modulus (E-y=22.23 g(f).mm(-2)) with different loads and in comparison with data from the literature (E(y)approximate to 20.4 g(f).mm(-2)). The properties of each segment of the aorta were defined in terms of compliance, resistance and inertance as a function of length, radius and thickness. The variable thickness was obtained using positive and negative molds. Total static compliance of the aorta model is about 1.125.10(-3) g(-1).cm(4).sec(2) (1.5 cm(3).mmHg(-1)). Measurements were performed both on numerical and physical models tin open and closed loop configuration). Data reported show pressure and flow waveforms along with input impedance modulus and phase. The results are in good agreement with data from the literature.
引用
收藏
页码:647 / 657
页数:11
相关论文
共 28 条
[1]   A NEW TEST CIRCULATORY-SYSTEM FOR RESEARCH IN CARDIOVASCULAR ENGINEERING [J].
ARABIA, M ;
AKUTSU, T .
ANNALS OF BIOMEDICAL ENGINEERING, 1984, 12 (01) :29-48
[2]   MULTI-BRANCHED MODEL OF THE HUMAN ARTERIAL SYSTEM [J].
AVOLIO, AP .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1980, 18 (06) :709-718
[3]   DEVELOPMENT OF MOCK CIRCULATION MODELS FOR THE ASSESSMENT OF COUNTERPULSATION SYSTEMS [J].
BOWLES, CT ;
NISHIMURA, K ;
SHAH, SS ;
CUMMING, DVE ;
PEPPER, JR ;
YACOUB, MH ;
CLARK, C ;
PATTISON, CW .
CARDIOVASCULAR RESEARCH, 1991, 25 (11) :901-908
[4]   COMPUTER IDENTIFICATION OF MODELS FOR THE ARTERIAL TREE INPUT IMPEDANCE - COMPARISON BETWEEN 2 NEW SIMPLE-MODELS AND 1ST EXPERIMENTAL RESULTS [J].
BURATTINI, R ;
GNUDI, G .
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 1982, 20 (02) :134-144
[5]  
Clemente F, 1997, Technol Health Care, V5, P449
[7]   DESIGN OF A HYDRAULIC ANALOG OF CIRCULATORY-SYSTEM FOR EVALUATING ARTIFICIAL HEARTS [J].
DONOVAN, FM .
BIOMATERIALS MEDICAL DEVICES AND ARTIFICIAL ORGANS, 1975, 3 (04) :439-449
[8]   MOCK CIRCULATORY-SYSTEM FOR IN-VITRO REPRODUCTION OF THE LEFT-VENTRICLE, THE ARTERIAL TREE AND THEIR INTERACTION WITH A LEFT-VENTRICULAR ASSIST DEVICE [J].
FERRARI, G ;
DELAZZARI, C ;
MIMMO, R ;
AMBROSI, D ;
TOSTI, G .
JOURNAL OF MEDICAL ENGINEERING & TECHNOLOGY, 1994, 18 (03) :87-95
[9]   A MODULAR NUMERICAL-MODEL OF THE CARDIOVASCULAR-SYSTEM FOR STUDYING AND TRAINING IN THE FIELD OF CARDIOVASCULAR PHYSIOPATHOLOGY [J].
FERRARI, G ;
DELAZZARI, C ;
MIMMO, R ;
TOSTI, G ;
AMBROSI, D .
JOURNAL OF BIOMEDICAL ENGINEERING, 1992, 14 (02) :91-107
[10]   Quality of life in breast cancer Part II: Psychological and spiritual well-being [J].
Ferrell, BR ;
Grant, M ;
Funk, B ;
Otis-Green, S ;
Garcia, N .
CANCER NURSING, 1998, 21 (01) :1-9