Enantioselective approach to the synthesis of cyclohexane carbocyclic nucleosides

被引：31

作者：

Wang, J

Busson, R

Blaton, N

Rozenski, J

Herdewijn, P

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, Med Chem Lab, B-3000 Louvain, Belgium

[2] Fac Pharmaceut Sci, B-3000 Louvain, Belgium

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 09期

关键词：

D O I：

10.1021/jo972285c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(R)-(-)-Carvone was used as starting material for the synthesis of a new series of 2-(hydroxymethyl)cyclohexane-1,3-diol nucleosides. The enantioselective precursors of the nucleoside analogues were obtained via a stereo-and regioselective hydroboration reaction. The compounds have equatorial oriented base moieties despite the presence of three other axial substituents.

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页码：3051 / 3058

页数：8

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