Homocysteine, 5,10 methylenetetrahydrofolate reductase and deep venous thrombosis. Study among 120 patients in internal medicine.

被引：18

作者：

Quere, I ^{[1
]}

Chasse, JF ^{[1
]}

Dupuy, E ^{[1
]}

Bellet, E ^{[1
]}

Molho-Sabatier, P ^{[1
]}

Tobelem, G ^{[1
]}

Janbon, C ^{[1
]}

机构：

[1] Hop St Eloi, Serv Med Interne B, F-34295 Montpellier, France

来源：

REVUE DE MEDECINE INTERNE | 1998年 / 19卷 / 01期

关键词：

homocysteine; C677T MTHFR; venous thrombosis; epidemiology;

D O I：

10.1016/S0248-8663(97)83696-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background. - In the last few years, the association of deep vein thrombosis with frequent biological risk factors and genetic polymorphisms has significantly modified the field of venous thrombosis. In this study, we measured plasma homocystein levels and tested the C677T methylentetrahydrofolate reductase (MTHFR) mutation. Patients and methods. - Plasma homocystein levels and test for C677T MTHFR mutation were performed in 120 consecutive patients with objectively diagnosed deep vein thrombosis, and in 120 controls. Results. - We found a strong association between hyperhomocysteinemia and thrombosis (odd ratio: 2.43 IC 95% [1.27-4.71]). Conversely the C677T MTHFR gene polymorphism is only associated with hyperhomocysteinemia but not associated with thrombosis. Conclusion. - This is a preliminary study to the ongoing international multicentric study of SNFMI (Societe nationale francaise de medecine interne) concerning hyperhomocysteinemia and venous thrombosis. (C) 1998, Elsevier, Paris.

引用

页码：29 / 33

页数：5

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