Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes

被引：65

作者：

Bornet, C ^{[1
]}

Chollet, R ^{[1
]}

Malléa, M ^{[1
]}

Chevalier, J ^{[1
]}

Davin-Regli, A ^{[1
]}

Pagès, JM ^{[1
]}

Bollet, C ^{[1
]}

机构：

[1] Univ Mediterranee, Fac Med, EA2197, IFR48, F-13385 Marseille 05, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 301卷 / 04期

关键词：

efflux pump; Enterobacter aerogenes; imipenem; efflux pump inhibitor; multidrug resistance;

D O I：

10.1016/S0006-291X(03)00074-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

imipenem is often used to treat intensive care unit patients infected by Enterobacter aerogenes, but it is leading to an increasing number of antibiotic resistant strains. Clinical isolates and imipenem resistant variants presented a high level of resistance to P-lactam antibiotic group and to chemically unrelated drugs. We report here that imipenem selects strains which contain active efflux pumps ejecting various unrelated antibiotics including quinolones, tetracycline, and chloramphenicol. An increase of AcrA, an efflux pump component, was observed in the imipenem resistant variants. The overexpression of marA, involved in the genetic control of membrane permeability via porin and efflux pump expression, indicated the activation of the resistance genetic cascade in imipenem resistant variants. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：985 / 990

页数：6

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