Hox genes in time and space during vertebrate body formation

被引：105

作者：

Iimura, Tadahiro

Pourquie, Olivier

机构：

[1] Howard Hughes Med Inst, Kansas City, MO 64110 USA

[2] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

DEVELOPMENT GROWTH & DIFFERENTIATION | 2007年 / 49卷 / 04期

关键词：

chromatin; collinearity; gastrulation; Hox; somite;

D O I：

10.1111/j.1440-169x.2007.00928.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Vertebrae display distinct morphological features at different levels of the body axis. Links between collinear Hox gene activation and the progressive mode of body axis elongation have provided a fascinating blueprint of the mechanisms for establishing these morphological identities. In this review, we first discuss the regulation and possible role of collinear Hox gene activation during body formation and then highlight the direct role of Hox genes in controlling cellular movements during gastrulation, therefore contributing to body formation. Additional related research aspects, such as imaging of chromatin regulation, roles of micro RNAs and evolutional findings are also discussed.

引用

页码：265 / 275

页数：11

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