Novel actions of leptin in the hippocampus

被引：28

作者：

Harvey, J ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Pharmacol & Neurosci, Dundee DD1 9SY, Scotland

来源：

ANNALS OF MEDICINE | 2003年 / 35卷 / 03期

关键词：

epilepsy; hippocampus; leptin; satiety signal; synaptic plasticity;

D O I：

10.1080/07853890310008251

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is well established that the obese gene product, leptin is an important circulating satiety factor that signals nutritional status to specific hypothalamic nuclei involved in body weight regulation. However, evidence is accumulating that, in addition to its pivotal role as an adiposity signal, leptin is a multi-faceted hormone that plays an important role in a plethora of CNS functions. In this review we summarize the recent advances made in leptin biology, with particular focus on its potential role as a cognitive enhancer and antiepileptic agent in the hippocampus.

引用

页码：197 / 206

页数：10

共 77 条

[1] EXCITOTOXICITY INDUCED BY ENHANCED EXCITATORY NEUROTRANSMISSION IN CULTURED HIPPOCAMPAL PYRAMIDAL NEURONS [J].

ABELE, AE ;

SCHOLZ, KP ;

SCHOLZ, WK ;

MILLER, RJ .

NEURON, 1990, 4 (03) :413-419

[2]

ALGER BE, 1988, J PHYSIOL-LONDON, V399, P191

[3] Activation of downstream signals by the long form of the leptin receptor [J].

Banks, AS ;

Davis, SM ;

Bates, SH ;

Myers, MG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (19) :14563-14572

[4] Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice [J].

Banks, WA ;

Clever, CM ;

Farrell, CL .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2000, 278 (06) :E1158-E1165

[5] Leptin enters the brain by a saturable system independent of insulin [J].

Banks, WA ;

Kastin, AJ ;

Huang, WT ;

Jaspan, JB ;

Maness, LM .

PEPTIDES, 1996, 17 (02) :305-311

[6] Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting [J].

Baskin, DG ;

Seeley, RJ ;

Kuijper, JL ;

Lok, S ;

Weigle, DS ;

Erickson, JC ;

Palmiter, RD ;

Schwartz, MW .

DIABETES, 1998, 47 (04) :538-543

[7] Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus [J].

Baskin, DG ;

Schwartz, MW ;

Seeley, RJ ;

Woods, SC ;

Porte, D ;

Breininger, JF ;

Jonak, Z ;

Schaefer, J ;

Krouse, M ;

Burghardt, C ;

Campfield, LA ;

Burn, P ;

Kochan, JP .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1999, 47 (03) :353-362

[8] The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors [J].

Baumann, H ;

Morella, KK ;

White, DW ;

Dembski, M ;

Bailon, PS ;

Kim, HK ;

Lai, CF ;

Tartaglia, LA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8374-8378

[9] Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a PI3-kinase mediated effect [J].

Berti, L ;

Kellerer, M ;

Capp, E ;

Haring, HU .

DIABETOLOGIA, 1997, 40 (05) :606-609

[10]

BIESSELS GJ, 1996, DIABETES, V43, P500

← 1 2 3 4 5 6 7 8 →