Novel actions of leptin in the hippocampus

被引：28

作者：

Harvey, J ^{[1
]}

机构：

[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Pharmacol & Neurosci, Dundee DD1 9SY, Scotland

来源：

ANNALS OF MEDICINE | 2003年 / 35卷 / 03期

关键词：

epilepsy; hippocampus; leptin; satiety signal; synaptic plasticity;

D O I：

10.1080/07853890310008251

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is well established that the obese gene product, leptin is an important circulating satiety factor that signals nutritional status to specific hypothalamic nuclei involved in body weight regulation. However, evidence is accumulating that, in addition to its pivotal role as an adiposity signal, leptin is a multi-faceted hormone that plays an important role in a plethora of CNS functions. In this review we summarize the recent advances made in leptin biology, with particular focus on its potential role as a cognitive enhancer and antiepileptic agent in the hippocampus.

引用

页码：197 / 206

页数：10

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