Chlamydial SET domain protein functions as a histone met hyltransferase

被引：37

作者：

Murata, Masayuki

Azuma, Yoshinao

Miura, Koshiro

Rahman, Mohd. Akhlakur

Matsutani, Minenosuke

Aoyama, Masahiro

Suzuki, Harumi

Sugi, Kazuro

Shirai, Mutsunori

机构：

[1] Yamaguchi Univ, Sch Med, Dept Microbiol & Immunol, Ube, Yamaguchi 7558505, Japan

[2] Natl Sanyo Hosp, Dept Clin Res, Ube, Yamaguchi 7550241, Japan

来源：

MICROBIOLOGY-SGM | 2007年 / 153卷

关键词：

t;

D O I：

10.1099/mic.0.29213-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

SET domain genes have been identified in numbers of bacterial genomes based on similarity to SET domains of eukaryotic histone methyltransferases. Herein, a Chlamydophila pneumoniae SET domain gene was clarified to be coincidently expressed with hctA and hctB genes encoding chlamydial histone H1-like proteins, Hc1 and Hc2, respectively. The SET domain protein (cpnSET) is localized in chlamydial cells and interacts with Hc1 and Hc2 through the C-terminal SET domain. As expected from conservation of catalytic sites in cpnSET, it functions as a protein methyltransferase to murine histone H3 and Hc1. However, little is known about protein methylation in the molecular pathogenesis of chlamydial infection. cpnSET may play an important role in chlamydial cell maturation due to modification of chlamydial histone H1-like proteins.

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页码：585 / 592

页数：8

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