NUCLEOID CONDENSATION IN ESCHERICHIA-COLI THAT EXPRESS A CHLAMYDIAL HISTONE HOMOLOG

被引：98

作者：

BARRY, CE

HAYES, SF

HACKSTADT, T

机构：

[1] NIAID, ROCKY MT LABS, INTRACELLULAR PARASITES LAB, HAMILTON, MT 59840 USA

[2] NIAID, ROCKY MT LABS, VECTORS & PATHOGENS LAB, STRUCT PATHOBIOL SECT, HAMILTON, MT 59840 USA

来源：

SCIENCE | 1992年 / 256卷 / 5055期

关键词：

D O I：

10.1126/science.256.5055.377

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chlamydial cell types are adapted for either extracellular survival or intracellular growth. In the transcriptionally inert elementary bodies, the chromosome is densely compacted; in metabolically active reticulate bodies, the chromatin is loosely organized. Condensation of the chlamydial nucleoid occurs concomitant with expression of proteins homologous to eukaryotic histone H1. When the Chlamydia trachomatis 18-kilodalton histone homolog Hcl is expressed in Escherichia coli, a condensed nucleoid structure similar to that of chlamydiae is observed with both light and electron microscopy. These results support a role for Hc1 in condensation of the chlamydial nucleoid.

引用

页码：377 / 379

页数：3

共 35 条

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