Drosophila in cancer research -: an expanding role

被引：82

作者：

Potter, CJ ^{[1
]}

Turenchalk, GS ^{[1
]}

Xu, T ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Genet, Howard Hughes Med Inst,Boyer Ctr Mol Med, New Haven, CT 06536 USA

来源：

TRENDS IN GENETICS | 2000年 / 16卷 / 01期

关键词：

D O I：

10.1016/S0168-9525(99)01878-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In recent years, Drosophila researchers have developed powerful genetic techniques that allow for the rapid identification and characterization of genes involved in tumor formation and development. The high level of gene and pathway conservation, the similarity of cellular processes and the emerging evidence of functional conservation of tumor suppressors between Drosophila and mammals, argue that studies of tumorigenesis in flies can directly contribute to the understanding of human cancer. In this review, we explore the historical and current roles of Drosophila in cancer research, as well as speculate on the future of Drosophila as a model to investigate cancer-related processes that are currently not well understood.

引用

页码：33 / 39

页数：7

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