Multiregional 1H-MRSI of the hippocampus, thalamus, and basal ganglia in schizophrenia

被引：31

作者：

Ende, G ^{[1
]}

Braus, DF ^{[1
]}

Walter, S ^{[1
]}

Weber-Fahr, W ^{[1
]}

Henn, FA ^{[1
]}

机构：

[1] Cent Inst Mental Hlth, NMR Res Psychiat, D-68159 Mannheim, Germany

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2003年 / 253卷 / 01期

关键词：

schizophrenia; N-acetylaspartate; hippocampus; basal ganglia; putamen;

D O I：

10.1007/s00406-003-0398-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background The hippocampus, thalamus and basal ganglia are among the brain regions of major interest in schizophrenia. Aims The purpose of this study was to corroborate previous findings of reduced N-acetylaspartate in the hippocampal and thalamic regions and to investigate possible metabolite changes in the putamen in schizophrenia. Method MRSI study of the thalamus, basal ganglia, and hippocampus in 13 schizophrenic patients under stable medication and age-matched healthy controls. Results A decrease of the N-acetylaspartate signal was found in the hippocampal region and the thalamus but not in the putamen of patients compared to controls. No significant group differences in the signals from creatine and phosphocreatine, and choline-containing compounds were found in the hippocampal region and the putamen but the signal from choline-containing compounds was decreased in the thalamus of patients. Conclusion Metabolic processes in the basal ganglia of schizophrenic patients seem to be opposite the hippocampal and thalamus findings.

引用

页码：9 / 15

页数：7