Chemical characterization of lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice

被引：181

作者：

Wu, Hua-Tao ^{[1
]}

He, Xue-Jun ^{[2
]}

Hong, Ying-Kai ^{[2
]}

Ma, Tao ^{[1
]}

Xu, Yan-Ping ^{[3
]}

Li, Hui-Hua ^{[3
]}

机构：

[1] Shantou Univ, Coll Med, Affiliated Hosp 1, Dept Gen Surg, Shantou 515041, Guangdong, Peoples R China

[2] Shantou Univ, Coll Med, Affiliated Hosp 1, Dept Urol, Shantou 515041, Guangdong, Peoples R China

[3] Shantou Univ, Cent Lab, Shantou 515041, Guangdong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2010年 / 46卷 / 05期

关键词：

High-fat diet; GC-MS; FT-IR; Mice; Lycium barbarum polysaccharides; NITRIC-OXIDE; RAT; MEMBRANE; HEART; MITOCHONDRIA; TISSUE;

D O I：

10.1016/j.ijbiomac.2010.02.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In this study, we investigated chemical structure of lycium barbarum polysaccharides and its modulatory effect on oxidative stress in high-fat mice. The polysaccharides mainly contained xylose and glucose. Little amount of rhamnose, mannose and galactose was observed. The lycium barbarum polysaccharides had IR bands at 800-1200 cm(-1), 1450-1800 cm(-1), 2500-3000 cm(-1), and 3200-3600 cm(-1), which were distinctive absorptions of polysaccharides. Rats are fed with high-fat diet for 2 months. Results showed that blood and liver antioxidant enzymes activities and GSH level in model mice significantly decreased, and MDA level significantly increased (P < 0.01) compared to normal control mice. Administration of lycium barbarum polysaccharides significantly increased antioxidant enzymes activities and decreased MDA level in mice (P < 0.01) compared to model group. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：540 / 543

页数：4