AMPA receptor biogenesis and trafficking

被引：112

作者：

Greger, Ingo H.

Esteban, Jose A.

机构：

[1] MRC, Div Neurobiol, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Univ Michigan, Sch Med, Dept Pharmacol, Ann Arbor, MI 48109 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2007年 / 17卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.conb.2007.04.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AMPA-type glutamate receptors mediate the majority of fast excitatory transmission in the central nervous system The trafficking of AMPA receptors to and from synapses alters synaptic strength and has been recognized as a central mechanism underlying various forms of synaptic plasticity. Both secretory and endocytic trafficking events seem to be driven by the subunit composition of AMPA receptor tetramers. Moreover, recent work suggests that synapses employ different tetramer combinations in response to altered synaptic input, suggesting the existence of signalling pathways that mediate remodelling of AMPA receptors. These latest developments and recent progress in elucidating the mechanisms that underlie channel assembly and trafficking are the subject of this review.

引用

收藏

页码：289 / 297

页数：9

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