Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

被引：311

作者：

Schomburg, L

Schweizer, U

Holtmann, B

Flohé, L

Sendtner, M

Köhrle, J

机构：

[1] Univ Berlin, Inst Expt Endokrinol, Klinikum Charite, D-10117 Berlin, Germany

[2] Univ Wurzburg, Neurol Klin, Inst Klin Neurobiol, D-97080 Wurzburg, Germany

[3] Abt Mol Innere Med, Med Poliklin, D-97070 Wurzburg, Germany

[4] Univ Berlin, Klinikum Charite, Neurowissensch Forschungszentrum, D-10117 Berlin, Germany

[5] Tech Univ Braunschweig, Inst Biochem, D-38124 Braunschweig, Germany

来源：

BIOCHEMICAL JOURNAL | 2003年 / 370卷

关键词：

glutathione peroxidase; selenium transport; targeted gene disruption; thioredoxin reductase;

D O I：

10.1042/BJ20021853

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Selenoprotein P (SePP), the major selenoprotein in plasma, has been implicated in selenium transport, selenium detoxification or antioxidant defence. We generated SePP-knockout mice that were viable, but exhibited reduced growth and developed ataxia. Selenium content was elevated in liver, but low in plasma and other tissues, and selenoenzyme activities changed accordingly. Our data reveal that SePP plays a pivotal role in delivering hepatic selenium to target tissues.

引用

页码：397 / 402

页数：6

共 35 条

[31] Analysis of the mouse selenoprotein P gene [J].