Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells

被引：41

作者：

LaPensee, Elizabeth W. ^{[1
]}

LaPensee, Christopher R. ^{[1
]}

Fox, Sejal ^{[1
]}

Schwemberger, Sandy ^{[2
]}

Afton, Scott ^{[3
]}

Ben-Jonathan, Nira ^{[1
]}

机构：

[1] Univ Cincinnati, Dept Canc & Cell Biol, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Shriners Burns Inst, Cincinnati, OH 45267 USA

[3] Univ Cincinnati, Dept Chem, Cincinnati, OH 45267 USA

来源：

CANCER LETTERS | 2010年 / 290卷 / 02期

关键词：

Breast cancer cells; Cisplatin; Bisphenol A; Estradiol; Estrogen receptors; Bcl-2; ESTROGEN-RECEPTOR; ENVIRONMENTAL ESTROGENS; LINE MCF-7; RESISTANCE; BINDING; DEATH; PROLIFERATION; EXPRESSION; APOPTOSIS; CHEMOTHERAPY;

D O I：

10.1016/j.canlet.2009.09.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Resistance to chemotherapy is a major problem facing breast cancer patients. Cisplatin, a highly effective DNA-damaging drug, has shown only little success in breast cancer treatment. We are reporting that low nanomolar doses of bisphenol A (BPA) or estradiol antagonize cisplatin cytotoxicity in breast cancer cells, with their effects not mediated via classical estrogen receptors. Although both compounds increase the expression of Bcl-2, a Bcl-2 inhibitor completely blocked the protective effects of BPA while only partially affecting those of estradiol. Blockade of BPA and E2 actions should sensitize ER-negative breast tumors to anti-cancer drugs and allow for the inclusion of cisplatin in treatment regimens. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：167 / 173

页数：7

共 36 条

[1]

Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer [J].

Coley, Helen M. .

CANCER TREATMENT REVIEWS, 2008, 34 (04) :378-390

[2]

Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients [J].

Dairkee, Shanaz H. ;

Seok, Junhee ;

Champion, Stacey ;

Sayeed, Aejaz ;

Mindrinos, Michael ;

Xiao, Wenzhong ;

Davis, Ronald W. ;

Goodson, William H. .

CANCER RESEARCH, 2008, 68 (07) :2076-2080

[3]

Platinum-based chemotherapy in metastatic breast cancer: current status [J].

Decatris, MP ;

Sundar, S ;

O'Byrne, KJ .

CANCER TREATMENT REVIEWS, 2004, 30 (01) :53-81

[4]

Effects of the environmental estrogens bisphenol A, o,p′-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7 [J].

Diel, P ;

Olff, S ;

Schmidt, S ;

Michna, H .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2002, 80 (01) :61-70

[5]

Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF [J].

Filardo, EJ ;

Quinn, JA ;

Bland, KI ;

Frackelton, AR .

MOLECULAR ENDOCRINOLOGY, 2000, 14 (10) :1649-1660

[6]

Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells [J].

Huang, Y ;

Ray, S ;

Reed, JC ;

Ibrado, AM ;

Tang, C ;

Nawabi, A ;

Bhalla, K .

BREAST CANCER RESEARCH AND TREATMENT, 1997, 42 (01) :73-81

[7]

LS14: A novel human adipocyte cell line that produces prolactin [J].

Hugo, ER ;

Brandebourg, TD ;

Comstock, CES ;

Gersin, KS ;

Sussman, JJ ;

Ben-Jonathan, N .

ENDOCRINOLOGY, 2006, 147 (01) :306-313

[8]

Bisphenol A at Environmentally Relevant Doses Inhibits Adiponectin Release from Human Adipose Tissue Explants and Adipocytes [J].

Hugo, Eric R. ;

Brandebourg, Terry D. ;

Woo, Jessica G. ;

Loftus, Jean ;

Alexander, J. Wesley ;

Ben-Jonathan, Nira .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2008, 116 (12) :1642-1647

[9]

Death and anti-death: Tumour resistance to apoptosis [J].

Igney, FH ;

Krammer, PH .

NATURE REVIEWS CANCER, 2002, 2 (04) :277-288

[10]

Development and evolution of therapies targeted to the estrogen receptor for the treatment and prevention of breast cancer [J].

Jordan, V. Craig ;

Brodie, Angela M. H. .

STEROIDS, 2007, 72 (01) :7-25

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