Synthesis of unsaturated analogues of 9-[2-(phosphonomethoxy)propyl]guanine as antiviral agents

被引：5

作者：

Franchetti, P ^{[1
]}

AbuSheikha, G ^{[1
]}

Perlini, P ^{[1
]}

Farhat, F ^{[1
]}

Grifantini, M ^{[1
]}

Perra, G ^{[1
]}

Milia, C ^{[1
]}

Putzolu, M ^{[1
]}

LaColla, P ^{[1
]}

Marongiu, ME ^{[1
]}

机构：

[1] UNIV CAGLIARI, DIPARTIMENTO BIOL SPERIMENTALE, I-09124 CAGLIARI, ITALY

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1997年 / 16卷 / 10-11期

关键词：

D O I：

10.1080/07328319708002544

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 9-[2-(phosphonomethoxy)allyl]guanine (1) and 9-[2(phosphonomethoxy)allyl]-8-aza-guanine (2), two new unsaturated acyclic phosphonate nucleosides analogues of the anti-HIV agents PMPG and 8-aza-PMPG, is described. Compounds 1 and 2 were evaluated for activity against human immunodeficiency virus(HIV-1 and HIV-2) and herpes simplex virus (HSV-1 and HSV-2).

引用

页码：1921 / 1932

页数：12

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