SYNTHESIS AND ANTIVIRAL ACTIVITY OF RIGID ACYCLONUCLEOTIDE ANALOGS

被引：23

作者：

CASARA, PJ

ALTENBURGER, JM

TAYLOR, DL

TYMS, AS

KENNY, M

NAVE, JF

机构：

[1] MARION MERRELL DOW INC,KANSAS CITY,MO 64137

[2] MRC,CTR COLLABORAT,LONDON NW7 1AD,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 12期

关键词：

D O I：

10.1016/0960-894X(95)00208-B

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis, anti-HIV-l and anti-herpesvirus activities of new rigid acyclonucleotide analogs are described. 9-[2-methylidene-3-(phosphonomethoxy)propyl]guanine 1a exhibits in vitro anti-HIV-1 activity similar to that of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Compound la is 9-fold less toxic to human T-lymphoid cells MT-4 than PMEA.

引用

页码：1275 / 1280

页数：6

共 19 条

[1] ACTIVATION BY THYMIDINE KINASE AND POTENT ANTIHERPETIC ACTIVITY OF 2'-NOR-2'-DEOXYGUANOSINE (2'NDG)
ASHTON, WT
KARKAS, JD
FIELD, AK
TOLMAN, RL
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 108 (04) : 1716 - 1721
[2] MARKED INVIVO ANTIRETROVIRUS ACTIVITY OF 9-(2-PHOSPHONYLMETHOXY-ETHYL)ADENINE, A SELECTIVE ANTI-HUMAN IMMUNODEFICIENCY VIRUS AGENT
BALZARINI, J
NAESENS, L
HERDEWIJN, P
ROSENBERG, I
HOLY, A
PAUWELS, R
BABA, M
JOHNS, DG
DECLERCQ, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (01) : 332 - 336
[3] INTRACELLULAR METABOLISM AND MECHANISM OF ANTIRETROVIRUS ACTION OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE, A POTENT ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS COMPOUND
BALZARINI, J
ZHANG, H
HERDEWIJN, P
JOHNS, DG
DECLERCQ, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) : 1499 - 1503
[4] DIFFERENTIAL ANTIHERPESVIRUS AND ANTIRETROVIRUS EFFECTS OF THE (S) AND (R) ENANTIOMERS OF ACYCLIC NUCLEOSIDE PHOSPHONATES - POTENT AND SELECTIVE INVITRO AND INVIVO ANTIRETROVIRUS ACTIVITIES OF (R)-9-(2-PHOSPHONOMETHOXYPROPYL)-2,6-DIAMINOPURINE
BALZARINI, J
HOLY, A
JINDRICH, J
NAESENS, L
SNOECK, R
SCHOLS, D
DECLERCQ, E
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (02) : 332 - 338
[5] DECLERCQ E, 1987, ANTIVIR RES, V8, P261
[6] A NEW CLASS OF ACYCLIC PHOSPHONATE NUCLEOTIDE ANALOGS - PHOSPHONATE ISOSTERES OF ACYCLOVIR AND GANCICLOVIR MONOPHOSPHATES AS ANTIVIRAL AGENTS
KIM, CU
MISCO, PF
LUH, BY
HITCHCOCK, MJM
GHAZZOULI, I
MARTIN, JC
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (07) : 2286 - 2294
[7] MILLER WH, 1980, J BIOL CHEM, V255, P7204
[8] DISSOCIATION OF GP120 FROM HIV-1 VIRIONS INDUCED BY SOLUBLE CD4
MOORE, JP
MCKEATING, JA
WEISS, RA
SATTENTAU, QJ
[J]. SCIENCE, 1990, 250 (4984) : 1139 - 1142
[9] 9-(PHOSPHONOALKYL)GUANINE DERIVATIVES AS SUBSTRATES OR INHIBITORS OF GUANYLATE KINASE
NAVE, JF
ESCHBACH, A
HALAZY, S
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 295 (02) : 253 - 257
[10] PHOSPHONYLMETHOXYETHYL PURINE DERIVATIVES, A NEW CLASS OF ANTI-HUMAN IMMUNODEFICIENCY VIRUS AGENTS
PAUWELS, R
BALZARINI, J
SCHOLS, D
BABA, M
DESMYTER, J
ROSENBERG, I
HOLY, A
DECLERCQ, E
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (07) : 1025 - 1030

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