Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

被引：20

作者：

Parolin, C

Borsetti, A

Choe, HY

Farzan, M

Kolchinsky, P

Heesen, M

Ma, Q

Gerard, C

Palú, G

Dorf, ME

Springer, T

Sodroski, J

机构：

[1] Dana Farber Canc Inst, Div Human Retrovirol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Ctr Blood Res, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Publ Hlth, Dept Canc Biol, Boston, MA 02115 USA

[5] Childrens Hosp, Ina Sue Perlmutter Lab, Boston, MA 02115 USA

[6] Beth Israel Hosp, Dept Med, Boston, MA 02215 USA

[7] Beth Israel Hosp, Dept Pediat, Boston, MA 02215 USA

[8] Harvard Univ, Sch Med, Boston, MA 02115 USA

[9] Univ Padua, Inst Microbiol, I-35121 Padua, Italy

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 02期

关键词：

D O I：

10.1128/JVI.72.2.1652-1656.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

引用

收藏

页码：1652 / 1656

页数：5

相关论文

共 64 条

[1] CC CKRS: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1 [J].

Alkhatib, G ;

Combadiere, C ;

Broder, CC ;

Feng, Y ;

Kennedy, PE ;

Murphy, PM ;

Berger, EA .

SCIENCE, 1996, 272 (5270) :1955-1958

[2]

[Anonymous], SCIENCE

[3] HUMAN-IMMUNODEFICIENCY-VIRUS ENVELOPE GLYCOPROTEIN CD4-MEDIATED FUSION OF NONPRIMATE CELLS WITH HUMAN-CELLS [J].

ASHORN, PA ;

BERGER, EA ;

MOSS, B .

JOURNAL OF VIROLOGY, 1990, 64 (05) :2149-2156

[4] Multiple extracellular elements of CCR5 and HIV-1 entry: Dissociation from response to chemokines [J].

Atchison, RE ;

Gosling, J ;

Monteclaro, FS ;

Franci, C ;

Digilio, L ;

Charo, IF ;

Goldsmith, MA .

SCIENCE, 1996, 274 (5294) :1924-1926

[5] ISOLATION OF A T-LYMPHOTROPIC RETROVIRUS FROM A PATIENT AT RISK FOR ACQUIRED IMMUNE-DEFICIENCY SYNDROME (AIDS) [J].

BARRESINOUSSI, F ;

CHERMANN, JC ;

REY, F ;

NUGEYRE, MT ;

CHAMARET, S ;

GRUEST, J ;

DAUGUET, C ;

AXLERBLIN, C ;

VEZINETBRUN, F ;

ROUZIOUX, C ;

ROZENBAUM, W ;

MONTAGNIER, L .

SCIENCE, 1983, 220 (4599) :868-871

[6] HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor [J].

Bieniasz, PD ;

Fridell, RA ;

Aramori, I ;

Ferguson, SSG ;

Caron, MG ;

Cullen, BR .

EMBO JOURNAL, 1997, 16 (10) :2599-2609

[7] The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry [J].

Bleul, CC ;

Farzan, M ;

Choe, H ;

Parolin, C ;

ClarkLewis, I ;

Sodroski, J ;

Springer, TA .

NATURE, 1996, 382 (6594) :829-833

[8] THE REGION OF THE ENVELOPE GENE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RESPONSIBLE FOR DETERMINATION OF CELL TROPISM [J].

CANN, AJ ;

CHURCHER, MJ ;

BOYD, M ;

OBRIEN, W ;

ZHAO, JQ ;

ZACK, J ;

CHEN, ISY .

JOURNAL OF VIROLOGY, 1992, 66 (01) :305-309

[9] IDENTIFICATION OF HIV-1 DETERMINANTS FOR T-LYMPHOID CELL-LINE INFECTION [J].

CARRILLO, A ;

TROWBRIDGE, DB ;

WESTERVELT, P ;

RATNER, L .

VIROLOGY, 1993, 197 (02) :817-824

[10] VIRAL DETERMINANTS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 T-CELL OR MACROPHAGE TROPISM, CYTOPATHOGENICITY, AND CD4 ANTIGEN MODULATION [J].

CHENGMAYER, C ;

QUIROGA, M ;

TUNG, JW ;

DINA, D ;

LEVY, JA .

JOURNAL OF VIROLOGY, 1990, 64 (09) :4390-4398

← 1 2 3 4 5 6 7 →