Modulation of the primary and the secondary antibody response by tobacco smoke condensates

被引：10

作者：

Van Binh, PN

Zhou, D

Baudouin, F

Martin, C

Radionoff, M

Dutertre, H

Marchand, V

Thevenin, M

Warnet, JM

Duc, HT ^{[1
]}

机构：

[1] Univ Paris 05, Fac Sci Pharmaceut & Biol, Toxicol Lab, F-75006 Paris, France

[2] Hop Paul Brousse, U602, Inst Andre Lwolff, INSERM, F-94807 Villejuif, France

[3] ARN, F-45404 Fleury Les Aubrais, France

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2004年 / 58卷 / 09期

关键词：

cigarette smoke condensates; antibody response;

D O I：

10.1016/j.biopha.2004.08.021

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cigarette smoke condensate administered to C57BL/6 mice led to a decrease in the primary antibody response to OVA (hen egg albumin) antigen. Selenium (Se)-supplementation allowed to relieve significantly this inhibition. Moreover, even being not supplemented with Se, a preparation was found devoid of inhibitory effects. Furthermore, the presence of Se-supplemented tobacco smoke condensate at the time of antigen priming, contributed to an enhanced secondary antibody response. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：527 / 530

页数：4

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