Modulation of the primary and the secondary antibody response by tobacco smoke condensates

被引:10
作者
Van Binh, PN
Zhou, D
Baudouin, F
Martin, C
Radionoff, M
Dutertre, H
Marchand, V
Thevenin, M
Warnet, JM
Duc, HT [1 ]
机构
[1] Univ Paris 05, Fac Sci Pharmaceut & Biol, Toxicol Lab, F-75006 Paris, France
[2] Hop Paul Brousse, U602, Inst Andre Lwolff, INSERM, F-94807 Villejuif, France
[3] ARN, F-45404 Fleury Les Aubrais, France
关键词
cigarette smoke condensates; antibody response;
D O I
10.1016/j.biopha.2004.08.021
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Cigarette smoke condensate administered to C57BL/6 mice led to a decrease in the primary antibody response to OVA (hen egg albumin) antigen. Selenium (Se)-supplementation allowed to relieve significantly this inhibition. Moreover, even being not supplemented with Se, a preparation was found devoid of inhibitory effects. Furthermore, the presence of Se-supplemented tobacco smoke condensate at the time of antigen priming, contributed to an enhanced secondary antibody response. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码:527 / 530
页数:4
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