Ultrasensitive detection of DNA hybridization using carbon nanotube field-effect transistors

被引：69

作者：

Maehashi, K

Matsumoto, K

Kerman, K

Takamura, Y

Tamiya, E

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan

[2] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan

[3] Japan Adv Inst Sci & Technol, Sch Mat Sci, Tatsunokuchi, Ishikawa 9231292, Japan

来源：

JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS | 2004年 / 43卷 / 12A期

关键词：

carbon nanotube field-effect transistors; DNA hybridization; PNA probe; ultrasensitivity; real time; label free;

D O I：

10.1143/JJAP.43.L1558

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We have sensitively detected DNA hybridization using carbon nanotube field-effect transistors (CNTFETs) in real time. Amino modified peptide nucleic acid (PNA) oligonucleotides at 5' end were covalently immobilized onto the Au surface of the back gate. For 11-mer PNA oligonucletide probe, full-complementary DNA with concentration as low as 6.8 fM solution could be effectively detected. Our CNTFET-based biochip is a promising candidate for the development of an integrated, high-throughput, multiplexed DNA biosensor for medical, forensic and environmental diagnostics.

引用

收藏

页码：L1558 / L1560

页数：3

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