Fruit and Vegetable Intake and Overall Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC)

被引：269

作者：

Boffetta, Paolo ^{[1
]}

Couto, Elisabeth ^{[1
]}

Wichmann, Janine ^{[2
,3
]}

Ferrari, Pietro ^{[4
]}

Trichopoulos, Dimitrios ^{[5
]}

Bueno-de-Mesquita, H. Bas ^{[6
]}

van Duijnhoven, Fraenzel J. B. ^{[6
,7
]}

Buchner, Frederike L. ^{[6
,8
]}

Key, Tim ^{[9
]}

Boeing, Heiner ^{[10
]}

Noethlings, Ute ^{[10
]}

Linseisen, Jakob ^{[11
]}

Gonzalez, Carlos A. ^{[12
]}

Overvad, Kim ^{[13
]}

Nielsen, Michael R. S. ^{[14
]}

Tjonneland, Anne ^{[15
]}

Olsen, Anja ^{[15
]}

Clavel-Chapelon, Francoise ^{[16
]}

Boutron-Ruault, Marie-Christine ^{[16
,34
]}

Morois, Sophie ^{[16
]}

Lagiou, Pagona ^{[5
]}

Naska, Androniki ^{[5
]}

Benetou, Vassiliki ^{[5
]}

Kaaks, Rudolf ^{[11
]}

Rohrmann, Sabine ^{[11
]}

Panico, Salvatore ^{[17
]}

Sieri, Sabina ^{[18
]}

Vineis, Paolo ^{[19
,20
]}

Palli, Domenico ^{[21
]}

van Gils, Carla H. ^{[7
]}

Peeters, Petra H. ^{[7
]}

Lund, Eiliv ^{[22
]}

Brustad, Magritt ^{[22
]}

Engeset, Dagrun ^{[22
]}

Maria Huerta, Jose ^{[23
,24
]}

Rodriguez, Laudina ^{[25
]}

Sanchez, Maria-Jose ^{[26
,27
]}

Dorronsoro, Miren ^{[28
,29
]}

Barricarte, Aurelio ^{[30
]}

Hallmans, Goran ^{[31
]}

Johansson, Ingegerd ^{[32
]}

Manjer, Jonas ^{[33
]}

Sonestedt, Emily ^{[34
]}

Allen, Naomi E. ^{[9
]}

Bingham, Sheila ^{[35
]}

Khaw, Kay-Tee ^{[35
]}

Slimani, Nadia ^{[1
]}

Jenab, Mazda ^{[1
]}

Mouw, Traci ^{[19
]}

Norat, Teresa ^{[19
]}

机构：

[1] Int Agcy Res Canc, Lifestyle & Canc Grp, F-69372 Lyon, France

[2] Univ Copenhagen, Environm Hlth Sect, Inst Publ Hlth, Copenhagen, Denmark

[3] Univ Pretoria, Sch Hlth Syst & Publ Hlth, ZA-0002 Pretoria, South Africa

[4] European Food Safety Author, Data Collect & Exposure Unit, Parma, Italy

[5] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[6] Natl Inst Publ Hlth & Environm RIVM, Ctr Nutr & Hlth, Bilthoven, Netherlands

[7] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[8] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol Biostatist & HTA, NL-6525 ED Nijmegen, Netherlands

[9] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[10] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany

[11] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[12] Bellvitge Inst Biomed Res IDIBELL, Unit Nutr Environm & Canc, Canc Epidemiol Res Programme, Catalan Inst Oncol, Barcelona, Spain

[13] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[14] Aarhus Univ Hosp, Dept Cardiol, Aalborg, Denmark

[15] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[16] Inst Gustave Roussy, INSERM, ERI20, EA 4045, F-94805 Villejuif, France

[17] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[18] Fdn IRCSS Ist Nazl Tumori, Dept Prevent & Predict Med, Nutr Epidemiol Unit, Milan, Italy

[19] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England

[20] Inst Sci Interchange Fdn, Turin, Italy

[21] Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[22] Univ Tromso, Inst Community Med, Tromso, Norway

[23] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[24] CIBERESP, Murcia, Spain

[25] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain

[26] Andalusian Sch Publ Hlth, Granada, Spain

[27] CIBERESP, Granada, Spain

[28] Basque Govt, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[29] CIBERESP, San Sebastian, Spain

[30] Inst Salud Publ, Pamplona, Spain

[31] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[32] Umea Univ, Dept Odontol, Umea, Sweden

[33] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[34] Lund Univ, Dept Clin Sci Malmonutr Epidemiol, Malmo, Sweden

[35] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2010年 / 102卷 / 08期

关键词：

LUNG-CANCER; CONSUMPTION; CALIBRATION; STOMACH; DISEASE;

D O I：

10.1093/jnci/djq072

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background It is widely believed that cancer can be prevented by high intake of fruits and vegetables. However, inconsistent results from many studies have not been able to conclusively establish an inverse association between fruit and vegetable intake and overall cancer risk. Methods We conducted a prospective analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to assess relationships between intake of total fruits, total vegetables, and total fruits and vegetables combined and cancer risk during 1992-2000. Detailed information on the dietary habit and lifestyle variables of the cohort was obtained. Cancer incidence and mortality data were ascertained, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox regression models. Analyses were also conducted for cancers associated with tobacco and alcohol after stratification for tobacco smoking and alcohol drinking. Results Of the initial 142 605 men and 335 873 women included in the study, 9604 men and 21 000 women were identified with cancer after a median follow-up of 8.7 years. The crude cancer incidence rates were 7.9 per 1000 person-years in men and 7.1 per 1000 person-years in women. Associations between reduced cancer risk and increased intake of total fruits and vegetables combined and total vegetables for the entire cohort were similar (200 g/d increased intake of fruits and vegetables combined, HR = 0.97, 95% CI = 0.96 to 0.99; 100 g/d increased intake of total vegetables, HR = 0.98, 95% CI = 0.97 to 0.99); intake of fruits showed a weaker inverse association (100 g/d increased intake of total fruits, HR = 0.99, 95% CI = 0.98 to 1.00). The reduced risk of cancer associated with high vegetable intake was restricted to women (HR = 0.98, 95% CI = 0.97 to 0.99). Stratification by alcohol intake suggested a stronger reduction in risk in heavy drinkers and was confined to cancers caused by smoking and alcohol. Conclusions A very small inverse association between intake of total fruits and vegetables and cancer risk was observed in this study. Given the small magnitude of the observed associations, caution should be applied in their interpretation. J Natl Cancer Inst 2010; 102: 529-537

引用

页码：529 / 537

页数：9

共 33 条

[1]

American Institute for Cancer Research/World Cancer Research Fund American Institute for Cancer Research, 1997, FOOD NUTR PREV CANC

[2]

[Anonymous], INT CLASS DIS ONC

[3]

[Anonymous], 2004, Tobacco smoke and involuntary smoking. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, V83, P53

[4]

[Anonymous], 2003, IARC HDB CANC PREV

[5]

[Anonymous], 2007, FOOD NUTR PHYS ACT P

[6] Carcinogenicity of alcoholic beverages [J].

Baan, Robert ;

Straif, Kurt ;

Grosse, Yann ;

Secretan, Beatrice ;

El Ghissassi, Fatiha ;

Bouvard, Veronique ;

Altieri, Andrea ;

Cogliano, Vincent .

LANCET ONCOLOGY, 2007, 8 (04) :292-293

[7] Vegetables and fruits in relation to cancer risk: Evidence from the Greek EPIC cohort study [J].

Benetou, Vassiliki ;

Orfanos, Philippos ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

Boffetta, Paolo ;

Trichopoulou, Antonia .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (02) :387-392

[8] Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract:: the prospective EPIC-study [J].

Boeing, Heiner ;

Dietrich, Thomas ;

Hoffmann, Kurt ;

Pischon, Tobias ;

Ferrari, Pietro ;

Lahmann, Petra H. ;

Boutron-Ruault, Marie Christine ;

Clavel-Chapelon, Francoise ;

Allen, Naomi ;

Key, Tim ;

Skeie, Guri ;

Lund, Eiliv ;

Olsen, Anja ;

Tjonneland, Anne ;

Overvad, Kim ;

Jensen, Majken K. ;

Rohrmann, Sabine ;

Linseisen, Jakob ;

Trichopoulou, Antonia ;

Bamia, Christina ;

Psaltopoulou, Theodora ;

Weinehall, Lars ;

Johansson, Ingegerd ;

Sanchez, Maria-Jose ;

Jakszyn, Paula ;

Ardanaz, Eva ;

Amiano, Pilar ;

Chirlaque, Maria Dolores ;

Quiros, J. Ramon ;

Wirfalt, Elisabet ;

Berglund, Goran ;

Peeters, Petra H. ;

van Gils, Carla H. ;

Bueno-de-Mesquita, H. Bas ;

Buchner, Frederike L. ;

Berrino, Franco ;

Palli, Domenico ;

Sacerdote, Carlotta ;

Tumino, Rosario ;

Panico, Salvatore ;

Bingham, Sheila ;

Khaw, Kay-Tee ;

Slimani, Nadia ;

Norat, Teresa ;

Jenab, Mazda ;

Riboli, Elio .

CANCER CAUSES & CONTROL, 2006, 17 (07) :957-969

[9] Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition [J].

Buechner, Frederike L. ;

Bueno-de-Mesquita, H. Bas ;

Ros, Martine M. ;

Kampman, Ellen ;

Egevad, Lars ;

Overvad, Kim ;

Raaschou-Nielsen, Ole ;

Tjonneland, Anne ;

Roswall, Nina ;

Clavel-Chapelon, Francoise ;

Boutron-Ruault, Marie-Christine ;

Touillaud, Marina ;

Chang-Claude, Jenny ;

Kaaks, Rudolf ;

Boeing, Heiner ;

Weikert, Steffen ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Trichopoulos, Dimitrios ;

Palli, Domenico ;

Sieri, Sabina ;

Vineis, Paolo ;

Tumino, Rosario ;

Panico, Salvatore ;

Vrieling, Alina ;

Peeters, Petra H. M. ;

van Gils, Carla H. ;

Lund, Eiliv ;

Gram, Inger T. ;

Engeset, Dagrun ;

Martinez, Carmen ;

Gonzalez, Carlos A. ;

Larranaga, Nerea ;

Ardanaz, Eva ;

Navarro, Carmen ;

Rodriguez, Laudina ;

Manjer, Jonas ;

Ehrnstrom, Roy A. ;

Hallmans, Goran ;

Ljungberg, Borje ;

Allen, Naomi E. ;

Roddam, Andrew W. ;

Bingham, Sheila ;

Khaw, Kay-Tee ;

Slimani, Nadia ;

Boffetta, Paolo ;

Jenab, Mazda ;

Mouw, Traci ;

Michaud, Dominique S. ;

Kiemeney, Lambertus A. L. M. .

INTERNATIONAL JOURNAL OF CANCER, 2009, 125 (11) :2643-2651

[10] Dealing with variability in food production chains: a tool to enhance the sensitivity of epidemiological studies on phytochemicals [J].

Dekker, M ;

Verkerk, R .

EUROPEAN JOURNAL OF NUTRITION, 2003, 42 (01) :67-72

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