The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence

被引：51

作者：

Fitzgerald, KA ^{[1
]}

O'Neill, LAJ

机构：

[1] Trinity Coll Dublin, Dept Biochem, Dublin 2, Ireland

[2] Trinity Coll Dublin, Inst Biotechnol, Dublin 2, Ireland

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 08期

关键词：

TIR domain; IL-1R; Toll and Spatzle;

D O I：

10.1016/S1286-4579(00)00396-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The IL-1 receptor/Toll-like receptor superfamily comprises a diverse family of cell surface receptors defined by a characteristic conserved sequence in their cytosolic regions, termed the Toll/IL-1 receptor domain, which function in inflammation and host defence against microbial pathogens. Members include receptors for the proinflammatory cytokines IL-1 and IL-18 and Toll-like receptors 2 and 4, which are involved in host responses to Gram-positive and Gram-negative bacteria, respectively. Signalling pathways activated by these receptors are conserved and the superfamily represents a pan-genomic system involved in the host response to infection and injury. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：933 / 943

页数：11

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