Bacterial gene regulation: from transcription attenuation to riboswitches and ribozymes

被引：34

作者：

Brantl, S ^{[1
]}

机构：

[1] Univ Jena, AG Bakteriengenet, D-07745 Jena, Germany

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 11期

关键词：

D O I：

10.1016/j.tim.2004.09.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the discovery of transcription attenuation as a mechanism of bacterial gene regulation, a broad variety of attenuation mechanisms have been unveiled and analysed. In 2002, the first convincing experimental evidence for metabolite-mediated attenuation, termed riboswitch, was published. Subsequently, riboswitches have been found to be widespread among bacteria and are also used in some eukaryotes. A surprising new finding has been a riboswitch acting as a metaboliteresponsive ribozyme - the first new naturally occurring ribozyme discovered since 1990.

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页码：473 / 475

页数：3

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