CD248/endosialin is dynamically expressed on a subset of stromal cells during lymphold tissue development, splenic remodeling and repair

被引：45

作者：

Lax, Sian

Hou, Tie Zheng

Jenkinson, Eric

Salmon, Mike

MacFadyen, John R.

Isacke, Clare M.

Anderson, Graham

Cunningham, Adam F.

Buckley, Christopher D. ^{[1
]}

机构：

[1] Univ Birmingham, Inst Biomed Res, Div Immun & Infect, MRC Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

[2] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

FEBS LETTERS | 2007年 / 581卷 / 18期

基金：

英国医学研究理事会;

关键词：

CD248; stromal cells; tissue repair; Salmonella;

D O I：

10.1016/j.febslet.2007.06.063

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Studies of stromal cell populations in lymphoid tissue (LT) have been hampered by a lack of selective markers. Here, we show that CD248 (Endosialin/TEMI) is a stromal marker that is differentially expressed on fibroblasts and pericytes in the thymus, lymph node and spleen. Expression is high during LT development but largely disappears in the adult. CD248 is re-expressed in a Salmonella-induced model of splenic enlargement; peak expression corresponding to the peak of splenic enlargement. These results suggest that CD248 expression helps define a subset of LT stromal cells which play a role in remodelling during tissue development, infection and repair. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：3550 / 3556

页数：7

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