Resistance is non-futile:: Resistance to Cry5B in the nematode Caenorhabditis elegans

被引：10

作者：

Barrows, Brad D. ^{[1
]}

Griffitts, Joel S. ^{[1
]}

Arolan, Raffi V. ^{[1
]}

机构：

[1] Univ Calif San Diego, Sect Cell & Dev Biol, La Jolla, CA 92093 USA

来源：

JOURNAL OF INVERTEBRATE PATHOLOGY | 2007年 / 95卷 / 03期

关键词：

Caenorhabditis elegans; Cry5B resistance; Cry toxin specificity; mutations in glycotransferase genes; glycolipid Cry toxin receptors; arthroseries glycolipids; mechanism of Cry toxin resistance;

D O I：

10.1016/j.jip.2007.04.002

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

The nematode, Caenorhabditis elegans, can be mutated to resistance to the Cry5B toxin of Bacillus thuringiensis. By cloning and characterization of these C. elegans resistance genes, we have determined that a major mechanism by which C. elegans resists Cry5B is by loss of function mutations in any one of four gylcosyltransferase genes that glycosylate glycolipids specific to arthropods. Without correct gylcosylation, binding of Cry5B is greatly impaired in C. elegans. That these specific arthroseries glycolipids do not occur in vertebrates potentially helps explain why Cry toxins are specific for arthropods. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：198 / 200

页数：3

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