Histone methyltransferases in cancer

被引：223

作者：

Albert, Mareike

Helin, Kristian ^{[1
]}

机构：

[1] Univ Copenhagen, BRIC, DK-2200 Copenhagen, Denmark

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 02期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

Histone methyltransferase; Epigenetics; Cancer; Polycomb group protein; Transcription; POLYCOMB GROUP PROTEIN; PARTIAL TANDEM DUPLICATION; ACUTE MYELOID-LEUKEMIA; TUMOR-SUPPRESSOR GENE; CELL SELF-RENEWAL; DOMAIN-CONTAINING GENE; MULTIPLE-MYELOMA; BREAST-CANCER; ZESTE HOMOLOG-2; E-CADHERIN;

D O I：

10.1016/j.semcdb.2009.10.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer is perceived as a heterogeneous group of diseases that is characterized by aberrant patterns of gene expression. In the last decade, an increasing amount of data has pointed to a key role for epigenetic alterations in human cancer. In this review, we focus on a subclass of epigenetic regulators, namely histone methyltransferases (HMTs). Several HMTs have been linked to different types of cancer; however, in most cases we only have limited knowledge regarding the molecular mechanisms by which the HMTs contribute to disease development. We summarize the current knowledge regarding some of the best-validated examples of HMTs contributing to tumorigenesis and discuss their potential mechanisms of action. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：209 / 220

页数：12

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