Enantioselective synthesis of 5-substituted pipecolic acids using an intramolecular allylsilane-iminium ion cyclization

被引:18
作者
Cellier, M
Gelas-Mialhe, Y [1 ]
Husson, HP
Perrin, B
Remuson, R
机构
[1] Univ Clermont Ferrand 2, UMR 6504, Lab Chim Subst Nat, F-63177 Clermont Ferrand, France
[2] Univ Paris 05, CNRS, UMR 8638, Chim Therapeut Lab,Fac Sci Pharmaceut & Biol, F-75270 Paris 06, France
关键词
D O I
10.1016/S0957-4166(00)00361-X
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The application of the intramolecular allylsilane-iminium ion cyclization reaction for the enantioselective synthesis of piperidine derivatives is described. The synthetic potential of this methodology is demonstrated by the enantioselective synthesis of 5-substituted pipecolic acids. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3913 / 3919
页数:7
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