The endothelium: physiological functions and role in microcirculatory failure during severe sepsis

被引：198

作者：

Ait-Oufella, H. ^{[1
,2
,3
]}

Maury, E. ^{[3
,4
,5
]}

Lehoux, S. ^{[6
]}

Guidet, B. ^{[3
,4
,5
]}

Offenstadt, G. ^{[3
,4
,5
]}

机构：

[1] Hop St Antoine, Serv Reanimat Med, F-75571 Paris 12, France

[2] PARCC, INSERM, U970, Paris, France

[3] Hop St Antoine, Serv Reanimat Med, AP HP, F-75012 Paris, France

[4] Univ Paris 06, UMR S707, F-75012 Paris, France

[5] INSERM, U707, F-75012 Paris, France

[6] McGill Univ, Lady Davis Inst Med Res, Montreal, PQ, Canada

来源：

INTENSIVE CARE MEDICINE | 2010年 / 36卷 / 08期

基金：

加拿大健康研究院;

关键词：

Endothelium; Sepsis; Coagulation; Cytokines; NITRIC-OXIDE SYNTHASE; DISSEMINATED INTRAVASCULAR COAGULATION; PLATELET-ACTIVATING-FACTOR; HUMAN VASCULAR ENDOTHELIUM; FACTOR PATHWAY INHIBITOR; TISSUE FACTOR; PROTEIN-C; L-ARGININE; E-SELECTIN; PROCOAGULANT ACTIVITY;

D O I：

10.1007/s00134-010-1893-6

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The endothelium is a highly dynamic cell layer that is involved in a multitude of physiological functions, including the control of vascular tone, the movement of cells and nutrients, the maintenance of blood fluidity and the growth of new vessels. During severe sepsis, the endothelium becomes proadhesive, procoagulant, antifibrinolytic and is characterized by alterations of vasomotor regulation. Most of these functions have been discovered using in vitro and animal models, but in vivo exploration of endothelium in patients remains difficult. New tools to analyze endothelial dysfunction at bedside have to be developed.

引用

页码：1286 / 1298

页数：13

共 132 条

[1] Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis -: A randomized controlled trial [J].

Abraham, E ;

Reinhart, K ;

Opal, S ;

Demeyer, I ;

Doig, C ;

Rodriguez, AL ;

Beale, R ;

Svoboda, P ;

Laterre, PF ;

Simon, S ;

Light, B ;

Spapen, H ;

Stone, J ;

Seibert, A ;

Peckelsen, C ;

De Deyne, C ;

Postier, R ;

Pettilä, V ;

Sprung, CL ;

Artigas, A ;

Percell, SR ;

Shu, V ;

Zwingelstein, C ;

Tobias, J ;

Poole, L ;

Stolzenbach, JC ;

Creasey, AA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (02) :238-247

[2] Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death [J].

Abraham, E ;

Laterre, P ;

Garg, R ;

Levy, H ;

Talwar, D ;

Trzaskoma, BL ;

Francois, B ;

Guy, JS ;

Bruckmann, M ;

Rea-Neto, A ;

Rossaint, R ;

Perrotin, D ;

Sablotzki, A ;

Arkins, N ;

Utterback, BG ;

Macias, WL .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (13) :1332-1341

[3] Endothelial cell heterogeneity [J].

Aird, WC .

CRITICAL CARE MEDICINE, 2003, 31 (04) :S221-S230

[4] Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment [J].

Aird, WC ;

Edelberg, JM ;

WeilerGuettler, H ;

Simmons, WW ;

Smith, TW ;

Rosenberg, RD .

JOURNAL OF CELL BIOLOGY, 1997, 138 (05) :1117-1124

[5] Vascular bed-specific hemostasis: Role of endothelium in pathogenesis [J].

Aird, WC .

CRITICAL CARE MEDICINE, 2001, 29 (07) :S28-S34

[6] Natural regulatory T cells control the development of atherosclerosis in mice [J].

Ait-Oufella, H ;

Salomon, BL ;

Potteaux, S ;

Robertson, AKL ;

Gourdy, P ;

Zoll, J ;

Merval, R ;

Esposito, B ;

Cohen, JL ;

Fisson, S ;

Flavell, RA ;

Hansson, GK ;

Klatzmann, D ;

Tedgui, A ;

Mallat, Z .

NATURE MEDICINE, 2006, 12 (02) :178-180

[7]

Allaire E, 1997, ANN THORAC SURG, V63, P582

[8] Platelets support pulmonary recruitment of neutrophils in abdominal sepsis [J].

Asaduzzaman, Muhammad ;

Lavasani, Shahram ;

Rahman, Milladur ;

Zhang, Su ;

Braun, Oscar O. ;

Jeppsson, Bengt ;

Thorlacius, Henrik .

CRITICAL CARE MEDICINE, 2009, 37 (04) :1389-1396

[9] DIFFERENTIATION OF ENDOTHELIAL-CELLS - ANALYSIS OF THE CONSTITUTIVE AND ACTIVATED ENDOTHELIAL-CELL PHENOTYPES [J].

AUGUSTIN, HG ;

KOZIAN, DH ;

JOHNSON, RC .

BIOESSAYS, 1994, 16 (12) :901-906

[10]

BARNATHAN ES, 1990, BLOOD, V76, P1795

← 1 2 3 4 5 6 7 8 9 10 →