Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease

被引：78

作者：

Rebeck, GW ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Alzheimer Res Unit, Charlestown, MA 02129 USA

来源：

NEUROSCIENCE LETTERS | 2000年 / 293卷 / 01期

关键词：

interleukin-1A; Alzheimer's disease; polymorphism;

D O I：

10.1016/S0304-3940(00)01487-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An association between altered risk of Alzheimer's disease (AD) and the interleukin-1A (IL-1A) gene was recently reported in two independent studies. Here, the IL-1A polymorphism was analyzed in a third population of 247 AD ;patients and 187 control individuals. In support of the published findings, the IL-1A 2/2 genotype was associated with an increased risk of early onset AD (odds ratio of 3.1, P = 0.02). Clinically, the IL-1A 2/2 genotype was associated with an earlier age of onset, but not with a change in the rate of progression of AD. (C) 2000 Elsevier Science Ireland Ltd. Ail rights reserved.

引用

页码：75 / 77

页数：3

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