RETRACTED: Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria (Publication with Expression of Concern. See vol. 129, pg. 868, 2016) (Retracted Article)

被引：130

作者：

Shulga, Nataly

Wilson-Smith, Robin ^{[2
]}

Pastorino, John G. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Dept Mol Biol, Ctr Sci, Sch Osteopath Med, Stratford, NJ 08084 USA

[2] Cooper Univ Hosp, RWJ Med Sch Camden, Div Gynecol Oncol, Dept OB GYN, Camden, NJ 08103 USA

来源：

JOURNAL OF CELL SCIENCE | 2010年 / 123卷 / 06期

关键词：

Sirtuin-3; Hexokinase II; Mitochondria; Cyclophilin D; PERMEABILITY TRANSITION-PORE; ADENINE-NUCLEOTIDE TRANSLOCASE; DEPENDENT ANION CHANNEL; CONTACT SITES; ADENYLATE TRANSLOCATOR; ENERGY-METABOLISM; SIR2; HOMOLOG; APOPTOSIS; COMPLEXES; CANCER;

D O I：

10.1242/jcs.061846

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We demonstrate that the transition from a reliance on glycolysis to oxidative phosphorylation in a transformed cell line is dependent on an increase in the levels and activity of sirtuin-3. Sirtuin-3 deacetylates cyclophilin D, diminishing its peptidyl-prolyl cis-trans isomerase activity and inducing its dissociation from the adenine nucleotide translocator. Moreover, the sirtuin-3-induced inactivation of cyclophilin D causes a detachment of hexokinase II from the mitochondria that is necessary for stimulation of oxidative phosphorylation. These results might have important implications for the role of sirtuin-3 in the metabolism of some cancer cells and their susceptibility to mitochondrial injury and cytotoxicity.

引用

页码：894 / 902

页数：9

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[1] Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1 - Mapping the site of binding [J].