Dynamic repositioning of CD4 and CD8 genes during T cell development

被引：26

作者：

Delaire, S ^{[1
]}

Huang, YH ^{[1
]}

Chan, SW ^{[1
]}

Robey, EA ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2004年 / 200卷 / 11期

关键词：

lineage commitment; heterochromatin; positive selection; gene repression; nuclear position;

D O I：

10.1084/jem.20041041

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although stable repression of CD4 and CD8 genes is a central feature of T cell lineage commitment, we lack detailed information about the timing and mechanism of this repression. Stable gene repression has been linked to the position of genes within the nucleus. Therefore, information about the nuclear position of CD4 and CD8 genes during T cell development could provide insights into both the mechanism of regulation of CD4 and CD8 genes, and the process of lineage commitment. Here, we report that lineage-specific repression of CD4 and CD8 genes is associated with the repositioning of alleles close to heterochromatin. We also provide evidence that the relocalization of CD4 and CD8 genes to heterochromatin can occur as an early response to positive selection signals. We discuss our results in terms of our current knowledge of CD4 and CD8 gene regulation and CD4 versus CD8 lineage commitment.

引用

页码：1427 / 1435

页数：9