Generation of intestinal T cells from progenitors residing in gut cryptopatches

被引：240

作者：

Saito, H

Kanamori, Y

Takemori, T

Nariuchi, H

Kubota, E

Takahashi-Iwanaga, H

Iwanaga, T

Ishikawa, H ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Microbiol, Tokyo 160, Japan

[2] Natl Inst Infect Dis, Dept Immunol, Tokyo 162, Japan

[3] Univ Tokyo, Inst Med Sci, Dept Allergol, Tokyo 108, Japan

[4] Kanagawa Dent Coll, Dept Oral & Maxillofacial Surg, Yokosuka, Kanagawa 238, Japan

[5] Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 060, Japan

[6] Hokkaido Univ, Grad Sch Vet Med, Lab Anat, Sapporo, Hokkaido 060, Japan

来源：

SCIENCE | 1998年 / 280卷 / 5361期

关键词：

D O I：

10.1126/science.280.5361.275

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cryptopatches (CPs) are part of the murine intestinal immune compartment, Cells isolated from CPs of the small intestine that were c-kit positive (c-kit(+)) but lineage markers negative (Lin(-)) gave rise to T cell receptor (TCR) alpha beta and TCR gamma delta intestinal intraepithelial T cells after in vivo transfer or tissue engraftment into severe combined immunodeficient mice. In contrast, cells from Peyer's patches and mesenteric lymph nodes, which belong in the same intestinal immune compartment but lack c-kit(+)Lin(-) cells, failed lo do so, These findings and results of electron microscopic analysis provide evidence of a local intestinal T cell precursor that develops in the CPs.

引用

页码：275 / 278

页数：4

共 47 条

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