Glomerular filtration of albumin: How small is the sieving coefficient?

被引:17
作者
Deen, WM
Lazzara, MJ
机构
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
[2] MIT, Biol Engn Div, Cambridge, MA 02139 USA
关键词
proximal tubule fluid; axial position; protein reabsorption; mass transfer coefficient;
D O I
10.1111/j.1523-1755.2004.09216.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
A model was developed to describe how the concentration of albumin in proximal tubule fluid will vary with axial position. including the effects of luminal flow and water and albumin reabsorption. The results show that the high albumin sieving coefficients proposed recently cannot be reconciled with micropuncture data in rats.
引用
收藏
页码:S63 / S64
页数:2
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