Substituted sulfonamides via a three component reaction on solid support

被引：72

作者：

Richter, H ^{[1
]}

Jung, G ^{[1
]}

机构：

[1] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(98)00429-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new scaffold for combinatorial chemistry has been developed. In a three component reaction using polymer bound acrylic acid, aldehydes and sulfonamides under Baylis-Hillman reaction conditions, substituted 2-methylidene-3-aminoarylsulfonylpropionic acids were synthesised. After cleavage from the solid support, the products were obtained in high purities. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2729 / 2730

页数：2

共 9 条

[1] The Baylis-Hillman reaction: A novel carbon-carbon bond forming reaction
Basavaiah, D
Rao, PD
Hyma, RS
[J]. TETRAHEDRON, 1996, 52 (24) : 8001 - 8062
[2] PHOSPHINE MEDIATED SYNTHESIS OF 2-METHYLIDENE-3-AMINO ESTERS AND KETONES
BERTENSHAW, S
KAHN, M
[J]. TETRAHEDRON LETTERS, 1989, 30 (21) : 2731 - 2732
[3] Recent developments in solid-phase organic synthesis
Brown, R
[J]. CONTEMPORARY ORGANIC SYNTHESIS, 1997, 4 (03): : 216 - 237
[4] Organic chemistry on solid supports
Fruchtel, JS
Jung, G
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (01): : 17 - 42
[5] Solid-phase organic reactions .2. A review of the literature Nov 95 Nov 96.
Hermkens, PHH
Ottenheijm, HCJ
Rees, DC
[J]. TETRAHEDRON, 1997, 53 (16) : 5643 - 5678
[6] PERLMUTTER P, 1995, AUST J CHEM, V48, P1541
[7] Prien O, 1997, SYNLETT, P325
[8] RICHTER H, 1997, 5 INT S SOL PHAS SYN
[9] RICHTER H, 1998, IN PRESS MOL DIVERSI

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