Cellular heterogeneity during vertebrate skeletal muscle development

被引：208

作者：

Biressi, Stefano

Molinaro, Mario

Cossu, Giulio

机构：

[1] Ist Sci San Raffaele, DiBiT, Stem Cell Res Inst, I-20132 Milan, Italy

[2] Univ Roma La Sapienza, Dept Histol & Med Embryol, I-00161 Rome, Italy

[3] Univ Milan, Dept Biol, I-20130 Milan, Italy

[4] Inst Cell Biol & Tissue Engn, I-00128 Rome, Italy

来源：

DEVELOPMENTAL BIOLOGY | 2007年 / 308卷 / 02期

关键词：

skeletal muscle; development; fiber diversity; myogenic lineage;

D O I：

10.1016/j.ydbio.2007.06.006

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although skeletal muscles appear superficially alike at different anatomical locations, in reality there is considerably more diversity than previously anticipated. Heterogeneity is not only restricted to completely developed fibers, but is clearly apparent during development at the molecular, cellular and anatomical level. Multiple waves of muscle precursors with different features appear before birth and contribute to muscular diversification. Recent cell lineage and gene expression studies have expanded our knowledge on how skeletal muscle is formed and how its heterogeneity is generated. This review will present a comprehensive view of relevant findings in this field. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：281 / 293

页数：13

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[11] Intrinsic phenotypic diversity of embryonic and fetal myoblasts is revealed by genome-wide gene expression analysis on purified cells [J].