Sickle cell disease: old discoveries, new concepts, and future promise

被引：230

作者：

Frenette, Paul S. ^{[1
]}

Atweh, George F. ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Div Hematol Oncol, Dept Med, New York, NY 10029 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 04期

关键词：

D O I：

10.1172/JCI30920

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.

引用

页码：850 / 858

页数：9

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