Sickle cell disease: old discoveries, new concepts, and future promise

被引：230

作者：

Frenette, Paul S. ^{[1
]}

Atweh, George F. ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Div Hematol Oncol, Dept Med, New York, NY 10029 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 04期

关键词：

D O I：

10.1172/JCI30920

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The discovery of the molecular basis of sickle cell disease was an important landmark in molecular medicine. The modern tools of molecular and cellular biology have refined our understanding of its pathophysiology and facilitated the development of new therapies. In this review, we discuss some of the important advances in this field and the impediments that limit the impact of these advances.

引用

页码：850 / 858

页数：9

共 129 条

[61] Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle mice [J].

Kaul, DK ;

Liu, XD ;

Choong, S ;

Belcher, JD ;

Vercellotti, GM ;

Hebbel, RP .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (01) :H293-H301

[62]

KAUL DK, 1993, BLOOD, V81, P2429

[63] Silent cerebral infarcts in sickle cell anemia: A risk factor analysis [J].

Kinney, TR ;

Sleeper, LA ;

Wang, WC ;

Zimmerman, RA ;

Pegelow, CH ;

Ohene-Frempong, K ;

Wethers, DL ;

Bello, JA ;

Vichinsky, EP ;

Moser, FG ;

Gallagher, DM ;

DeBaun, MR ;

Platt, OS ;

Miller, ST .

PEDIATRICS, 1999, 103 (03) :640-645

[64]

Kinney TR, 1999, BLOOD, V94, P1550

[65] 2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia [J].

Koshy, M ;

Dorn, L ;

Bressler, L ;

Molokie, R ;

Lavelle, D ;

Talischy, N ;

Hoffman, R ;

van Overveld, W ;

DeSimone, J .

BLOOD, 2000, 96 (07) :2379-2384

[66] PROPHYLACTIC RED-CELL TRANSFUSIONS IN PREGNANT PATIENTS WITH SICKLE-CELL DISEASE - A RANDOMIZED COOPERATIVE STUDY [J].

KOSHY, M ;

BURD, L ;

WALLACE, D ;

MOAWAD, A ;

BARON, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (22) :1447-1452

[67] SURGERY AND ANESTHESIA IS SICKLE-CELL DISEASE [J].

KOSHY, M ;

WEINER, SJ ;

MILLER, ST ;

SLEEPER, LA ;

VICHINSKY, E ;

BROWN, AK ;

KHAKOO, Y ;

KINNEY, TR .

BLOOD, 1995, 86 (10) :3676-3684

[68] The methylene tetrahydrofolate reductase (C677T) mutation as a potential risk factor for avascular necrosis in sickle cell disease [J].

Kutlar, A ;

Kutlar, F ;

Turker, I ;

Tural, C .

HEMOGLOBIN, 2001, 25 (02) :213-217

[69] Sickle cell disease: A multigenic perspective of a single gene disorder [J].

Kutlar, AK .

HEMATOLOGY, 2005, 10 :92-99

[70] Hospitalization rates and costs of care of patients with sickle-cell anemia in the State of Maryland in the era of hydroxyurea [J].

Lanzkron, Sophie ;

Haywood, Carlton, Jr. ;

Segal, Jodi B. ;

Dover, George J. .

AMERICAN JOURNAL OF HEMATOLOGY, 2006, 81 (12) :927-932

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