Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice

被引:323
作者
Watase, K
Hashimoto, K
Kano, M
Yamada, K
Watanabe, M
Inoue, Y
Okuyama, S
Sakagawa, T
Ogawa, S
Kawashima, N
Hori, S
Takimoto, M
Wada, K
Tanaka, K [1 ]
机构
[1] Natl Inst Neurosci, Dept Degenerat Neurol Dis, Tokyo 187, Japan
[2] Jichi Med Sch, Dept Physiol, Minami Kawachi, Tochigi 32904, Japan
[3] Inst Phys & Chem Res, Frontier Res Program, Lab Neuronal Signal Transduct, Wako, Saitama 35101, Japan
[4] Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 060, Japan
[5] Taisho Pharmaceut Co Ltd, Lab Med Res Labs 1, Ohmiya, Saitama 330, Japan
[6] Taisho Pharmaceut Co Ltd, Lab Anim Ctr, Ohmiya, Saitama 330, Japan
[7] Ciba Geigy Japan, Int Res Labs, Takarazuka, Hyogo 665, Japan
[8] Japan Sci & Technol Corp, Kawaguchi, Saitama, Japan
关键词
Bergmann glia; excitotoxic cerebellar damage; gene disruption; glial glutamate transporter; multiple climbing fibre innervation;
D O I
10.1046/j.1460-9568.1998.00108.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To study the function of GLAST, a glutamate transporter highly expressed in the cerebellar Bergmann astrocytes, the mouse GLAST gene was inactivated, GLAST-deficient mice developed normally and could manage simple coordinated tasks, such as staying on a stationary or a slowly rotating rod, but failed more challenging task such as staying on a quickly rotating rod. Electrophysiological examination revealed that Purkinje cells in the mutant mice remained to be multiply innervated by climbing fibres even at the adult stage, We also found that oedema volumes in the mutant mice increased significantly after cerebellar injury, These results indicate that GLAST plays active roles both in the cerebellar climbing fibre synapse formation and in preventing excitotoxic cerebellar damage after acute brain injury.
引用
收藏
页码:976 / 988
页数:13
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